GREMLIN Database
YUZM - Uncharacterized protein YuzM
UniProt: C0H3R1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 81 (74)
Sequences: 109 (93)
Seq/√Len: 10.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_F42_Q3.4820.98
25_M29_N3.3120.97
57_H61_D2.8740.93
29_N36_A2.4860.86
14_I39_M2.3710.83
51_E55_V2.3140.81
33_M56_G2.1370.76
25_M36_A2.1240.75
56_G60_H2.0690.73
27_N55_V2.0040.71
26_L70_L1.9580.69
5_Q50_Q1.6810.56
58_M62_H1.6760.56
51_E61_D1.5640.51
32_A56_G1.4930.47
7_S14_I1.4920.47
19_H26_L1.4800.47
45_D48_L1.2960.38
14_I42_Q1.2930.38
32_A58_M1.2670.37
27_N47_T1.2350.36
4_Q10_P1.2270.35
66_I69_H1.2130.35
61_D65_R1.2070.34
22_L75_Q1.1740.33
7_S39_M1.1720.33
38_F52_L1.1560.32
15_S48_L1.1410.32
32_A71_Q1.1360.31
7_S43_C1.1290.31
19_H45_D1.1080.30
66_I76_Q1.1030.30
41_Q49_K1.0440.28
46_Q63_Y1.0130.27
26_L52_L0.9990.26
5_Q44_Q0.9850.26
9_M76_Q0.9830.25
4_Q69_H0.9790.25
31_L45_D0.9670.25
9_M66_I0.9540.24
55_V68_K0.9520.24
39_M48_L0.9510.24
33_M74_Q0.9350.24
9_M12_S0.8880.22
10_P42_Q0.8690.22
15_S67_L0.8540.21
5_Q75_Q0.8430.21
3_N45_D0.8420.21
23_N73_G0.8350.20
9_M29_N0.8280.20
38_F47_T0.8210.20
68_K76_Q0.8050.20
53_D74_Q0.8010.19
23_N29_N0.7960.19
39_M50_Q0.7890.19
6_Q68_K0.7870.19
26_L66_I0.7830.19
60_H64_Q0.7740.19
22_L72_P0.7730.19
31_L53_D0.7720.19
25_M66_I0.7650.18
11_P18_D0.7630.18
16_T70_L0.7600.18
23_N53_D0.7550.18
5_Q26_L0.7520.18
9_M75_Q0.7500.18
4_Q14_I0.7440.18
23_N27_N0.7420.18
50_Q55_V0.7320.17
14_I71_Q0.7310.17
42_Q68_K0.7200.17
3_N44_Q0.7190.17
3_N33_M0.7110.17
3_N75_Q0.6970.17
15_S54_R0.6780.16
36_A43_C0.6690.16
46_Q49_K0.6680.16
12_S73_G0.6670.16
16_T31_L0.6660.16
13_V71_Q0.6630.16
12_S19_H0.6560.15
36_A66_I0.6370.15
16_T20_L0.6270.15
51_E54_R0.6230.15
36_A52_L0.6190.15
65_R72_P0.6120.14
37_H56_G0.6100.14
27_N67_L0.5890.14
48_L71_Q0.5880.14
12_S43_C0.5870.14
18_D62_H0.5850.14
41_Q66_I0.5850.14
19_H60_H0.5840.14
45_D67_L0.5790.14
15_S20_L0.5690.13
22_L27_N0.5680.13
9_M26_L0.5530.13
12_S72_P0.5520.13
26_L37_H0.5510.13
14_I22_L0.5500.13
16_T46_Q0.5500.13
16_T37_H0.5460.13
16_T26_L0.5460.13
41_Q61_D0.5450.13
44_Q65_R0.5400.13
7_S33_M0.5290.13
11_P58_M0.5280.13
41_Q46_Q0.5260.13
8_Q76_Q0.5090.12
20_L26_L0.5040.12
7_S12_S0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rbdA 4 0.9136 90.5 0.875 Contact Map
4etrA 1 0.7778 78.5 0.893 Contact Map
4am5A 6 0.8642 34.9 0.92 Contact Map
2fzfA 2 0.9012 32.5 0.921 Contact Map
2e0zA 8 0 25.2 0.925 Contact Map
4di0A 2 0.8519 24.4 0.926 Contact Map
1vjxA 1 0.9012 20.6 0.928 Contact Map
1nfvA 7 0.9012 19.1 0.929 Contact Map
2gyqA 2 0.9259 16.6 0.931 Contact Map
3k6cA 5 0.9136 13 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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