GREMLIN Database
YUZN - Uncharacterized HTH-type transcriptional regulator YuzN
UniProt: C0H3Q8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 92 (80)
Sequences: 499 (221)
Seq/√Len: 24.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_T51_A4.9841.00
27_R34_E3.7721.00
60_E74_R3.5301.00
63_G79_N2.5220.99
20_I35_L2.4320.98
23_E30_L2.3860.98
36_T54_K2.2390.97
50_Q53_A2.0770.96
86_L89_G2.0550.95
31_T73_Y1.8640.92
36_T50_Q1.7500.90
52_I78_F1.6730.88
51_A54_K1.6720.87
13_G78_F1.5540.83
63_G67_S1.5320.82
29_E77_I1.3880.76
25_S83_L1.3630.74
32_L76_L1.3360.73
57_S65_V1.3190.72
9_F79_N1.3110.71
10_K14_D1.3080.71
54_K83_L1.2940.70
6_D47_I1.2930.70
32_L50_Q1.2810.69
57_S60_E1.2590.68
46_S61_D1.2510.68
32_L45_L1.1560.61
10_K57_S1.1470.61
19_L31_T1.1290.59
61_D74_R1.1240.59
63_G66_T1.1200.59
36_T72_K1.0940.57
44_D53_A1.0850.56
63_G84_K1.0810.56
14_D86_L0.9750.48
23_E44_D0.9670.48
73_Y83_L0.9590.47
25_S81_E0.9520.47
50_Q76_L0.9400.46
50_Q57_S0.9280.45
69_R74_R0.9010.43
35_L73_Y0.8960.43
12_L78_F0.8950.43
20_I44_D0.8930.43
84_K87_L0.8880.42
19_L88_K0.8790.42
46_S80_N0.8740.41
27_R44_D0.8720.41
28_N77_I0.8690.41
47_I52_I0.8680.41
53_A57_S0.8640.40
20_I47_I0.8520.40
6_D27_R0.8480.39
66_T79_N0.8390.39
47_I89_G0.8390.39
6_D52_I0.8140.37
24_L30_L0.8000.36
36_T51_A0.7940.36
67_S74_R0.7890.35
25_S65_V0.7830.35
22_D89_G0.7790.35
21_L89_G0.7780.35
7_A61_D0.7750.34
22_D69_R0.7570.33
23_E73_Y0.7520.33
8_I13_G0.7410.32
15_S68_K0.7400.32
56_L60_E0.7390.32
33_Y53_A0.7230.31
13_G91_I0.7170.31
16_T69_R0.7050.30
34_E73_Y0.7010.30
78_F88_K0.6940.29
9_F86_L0.6940.29
27_R33_Y0.6930.29
66_T78_F0.6910.29
16_T45_L0.6900.29
33_Y66_T0.6880.29
47_I80_N0.6880.29
83_L86_L0.6810.29
57_S83_L0.6810.29
15_S19_L0.6790.29
29_E32_L0.6740.28
28_N84_K0.6660.28
10_K70_K0.6580.27
51_A87_L0.6570.27
29_E79_N0.6530.27
28_N50_Q0.6520.27
50_Q54_K0.6500.27
35_L85_N0.6450.27
48_T54_K0.6420.26
10_K68_K0.6390.26
6_D28_N0.6300.26
9_F46_S0.6090.25
20_I30_L0.6020.24
68_K85_N0.5990.24
28_N76_L0.5860.23
7_A69_R0.5830.23
86_L91_I0.5800.23
26_E58_V0.5800.23
34_E86_L0.5740.23
52_I62_A0.5740.23
31_T35_L0.5730.23
47_I54_K0.5710.23
70_K73_Y0.5570.22
16_T46_S0.5550.22
27_R66_T0.5550.22
10_K69_R0.5440.21
25_S33_Y0.5390.21
18_R71_G0.5360.21
30_L34_E0.5340.21
20_I56_L0.5270.20
80_N85_N0.5240.20
31_T75_V0.5240.20
22_D90_W0.5240.20
19_L35_L0.5170.20
16_T19_L0.5160.20
25_S28_N0.5050.19
26_E70_K0.5020.19
24_L72_K0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r1tA 2 0.9239 99.3 0.67 Contact Map
1q1hA 1 0.8478 99.2 0.679 Contact Map
2jscA 2 0.8913 99.2 0.683 Contact Map
1u2wA 2 0.9348 99.2 0.684 Contact Map
1r1uA 2 0.9239 99.2 0.691 Contact Map
2qlzA 2 0.8587 99.1 0.692 Contact Map
2zkzA 2 0.913 99.1 0.693 Contact Map
2kkoA 2 0.913 99.1 0.693 Contact Map
2p4wA 2 0.913 99.1 0.7 Contact Map
4k2eA 2 0.9239 99.1 0.7 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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