Pfam: PF01899 MNHE
Co-evolution data: Q7WY60
Function (from Uniprot):
- The N-terminal region is transmembrane and is not converged in the model due to no contacts with rest of structure.
- Mrp complex is a Na+/H+ antiporter that is considered to be the major Na+ excretion system in B.subtilis. Has a major role in Na+ resistance and a minor role in Na+- and K+-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na+/H+ antiporter, although the six other Mrp proteins are all required for Na+/H+ antiport activity and Na+ resistance. MrpA is required for initiation of sporulation when external Na+ concentration increases. Also transports Li+ but not K+, Ca2+ or Mg2+.